Publications - MIACYC Project
2025
- Evolution of CYP71D drives the diversification of monoterpene indole alkaloid biosynthesis in Gentianales
- Editorial overview : Physiology and metabolism 2024
- Translating community-wide spectral library into actionable chemical knowledge: a proof of concept with monoterpene indole alkaloids
- Geissoschizine Cyclase: A Discovery Revolutionizing the Understanding and Synthesis of Pharmacologically Important Monoterpenoid Indole Alkaloids
- A GAME changer in steroidal metabolite biosynthesis
2024
- Metabolic engineering of the paclitaxel anticancer drug
- Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine
- A GAME changer in steroidal metabolite biosynthesis
- Genome-based discovery of pachysiphine synthases in Tabernaemontana elegans
- The Madagascar palm genome provides new insights on the evolution of Apocynaceae specialized metabolism.
- Emerging trends in plant natural products biosynthesis: a chemical perspective
- Structural diversity and chemical logic underlying the assembly of monoterpene indole alkaloids oligomers
- A chromosome-scale genome assembly of Rauvolfia tetraphylla facilitates identification of the complete ajmaline biosynthetic pathway
- SPOTLIGHT: Alpha carbonic anhydrases join the club of alkaloid biosynthetic enzymes
- Emerging trends in production of plant natural products and new-to-nature biopharmaceuticals in yeast.
- Combination of Machine Learning and Empirical Computation for the Structural Validation of Trirosaline, a Natural Trimeric Monoterpene Indole Alkaloid from Catharanthus roseus
- Unlocking plant bioactive pathways: omics data harnessing and machine learning assisting
2023
- The evolutionary pattern of cocaine and hyoscyamine biosynthesis provides strategies to produce tropane alkaloids
- Convergent evolution for antibiotic biosynthesis in bacteria and animals
- From the Spectroscopic Reassessment of Authentic Alkaloid Samples to the Molecular Networking-Guided Discovery of Criophylline-Related Analogues from Callichilia inaequalis
- Structure elucidation of an aspidofractinine-type monoterpene indole alkaloid from Melodinus reticulatus
- The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids in monoterpene indole alkaloid synthesis
- Unifying the configuration of historical alkaloids from Borreria capitata through an extensive spectroscopic reinvestigation.
- From the Spectroscopic Reassessment of Authentic Alkaloid Samples to the Molecular Networking-Guided Discovery of Criophylline-Related Analogues from Callichilia inaequalis
- Gaining access to acetyl-CoA by peroxisomal surface display.
- Medicinal plants enter the single-cell multi-omics era
- Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast
- Artificial intelligence for natural product drug discovery
- On the structures of the penduflorines from Tabernaemontana penduliflora
2022
- An updated version of the Madagascar periwinkle genome
- Tonoplast and Peroxisome Targeting of γ-tocopherol N-methyltransferase Homologs Involved in the Synthesis of Monoterpene Indole Alkaloids
- Pyrrovobasine, hybrid alkylated pyrraline monoterpene indole alkaloid pseudodimer discovered using a combination of mass spectral and NMR-based machine learning annotations.
- Emerging mechanistic insights into the regulation of specialized metabolism in plants
- Boosting lignan-precursor synthesis in yeast cell factories through co-factor supply optimization
- Genome Assembly of the Medicinal Plant Voacanga thouarsii
- A new path for terpenoid biosynthesis
- Towards a Better Understanding of Toxin Biosynthesis in Seaweeds
- More than a Catharanthus plant: A multicellular and pluri-organelle alkaloid-producing factory
- Computer-Assisted Design of Sustainable Syntheses of Pharmaceuticals and Agrochemicals from Industrial Wastes
- The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis
- Chromosome-scale genomes throw light on plant drug biosynthesis
- Identification of a second 16-hydroxytabersonine-O-methyltransferase suggests an evolutionary relationship between alkaloid and flavonoid metabolisms in Catharanthus roseus
- Social amoebae as a new chassis for drug production
2021
- Efficient Terpene Production by Marine Thraustochytrids: Shedding Light on the Thermodynamic Driving Force
- Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits
- Reappraisal of the Structure of Lyaline as the First Naturally Occurring Nacycline Monoterpene Indole Alkaloid.
- Structure Reassignment of Melonine and Quantum-Chemical Calculations-Based Assessment of Biosynthetic Scenari
- Computational biotechnology guides elucidation of the biosynthesis of the plant anticancer drug camptothecin
- Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches
- Peroxisome : a new hub for metabolic engineering in yeast
- Marine drugs: Biology, pipelines, current and future prospects for production
- Yeasts as Biopharmaceutical Production Platforms
MIACYC
a collaborative research project
"CE43 Bioéconomie, chimie, biotechnologie, procédés et approches système, de la biomasse aux usages"
They talked about us!
"La Faculté de Pharmacie de Tours, lauréate de l’appel d’offre 2020 de l’ANR avec son projet MIACYC"
NOVEMBER 12, 2020
"Un financement ANR obtenu pour produire par bioingénierie des médicaments d'origine végétale et lutter contre leur pénurie"
OCTOBER 21, 2020
