Partager
Ecouter
Actualité

Emerging mechanistic insights into the regulation of specialized metabolism in plants

  • Santé-Sciences-Technologie,
  • Pharmacie,
Date(s)

du 23 décembre 2022 au 23 décembre 2025

Lieu(x)

Site Grandmont

EA2106 BBV - Biomolécules et Biotechnologies végétales

Published in Nature Plants, this review focuses on translational, transcriptional, epigenetic and chromatin-based regulation and evolution of specialized metabolism genes, a new and forefront research filed. We extrapolate to medicinal plants that synthetize rare molecules and also discuss how this new knowledge could help in improving strategies to produce useful plant-derived pharmaceuticals.

Méteignier LV, Nützmann HW, Papon N, Osbourn A, Courdavault V. Emerging mechanistic insights into the regulation of specialized metabolism in plants. Nat Plants. 2022 . doi: 10.1038/s41477-022-01288-7.
 

Abstract

Plants biosynthesize a broad range of natural products through specialized and species-specific metabolic pathways that are fuelled by core metabolism, together forming a metabolic network. Specialized metabolites have important roles in development and adaptation to external cues, and they also have invaluable pharmacological properties. A growing body of evidence has highlighted the impact of translational, transcriptional, epigenetic and chromatin-based regulation and evolution of specialized metabolism genes and metabolic networks. Here we review the forefront of this research field and extrapolate to medicinal plants that synthetize rare molecules. We also discuss how this new knowledge could help in improving strategies to produce useful plant-derived pharmaceuticals.