Peroxisome : a new hub for metabolic engineering in yeast

"Peroxisomes: A New Hub for Metabolic Engineering in Yeast"   by Natalja Kulagina, Sébastien Besseau, Nicolas Papon and Vincent Courdavault
DOI: 10.3389/fbioe.2021.659431

Keywords : peroxisomes, yeast, compartmentalization, metabolic engineering, heterologous production
Abstract : Microbial cell factories for heterologous production of high-value compounds recently emerged as a cost-effective and sustainable alternative to conventional production. However, these metabolic engineering approaches face multiple limitations due to the complexity of reconstituted biosynthetic pathways, including cytotoxicity and undesired cross-talk/competition with native components. To address such an issue in heterologous production, the peroxisome progressively stands out as one of the most promising candidates due to its advantageous properties. Here, we shed light on the advantages of employing peroxisomes in the context of spatial reconfiguration and compile the recent breakthrough in yeast peroxisome engineering. Specifically, we will highlight several outstanding recent articles, including the work of Gerhard H. Braus' team published in this special issue, which demonstrate the remarkable efficiency and relevance of peroxisomes as microfactories. Perspectives for industrial-scale heterologous production of valuable metabolites by microbial cell factories are also discussed