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A new path for terpenoid biosynthesis

  • Santé-Sciences-Technologie,
  • Pharmacie,
Date(s)

du 29 juillet 2022 au 29 juillet 2025

Lieu(x)

Site Grandmont

EA2106 BBV - Biomolécules et Biotechnologies végétales

Our spotlight on the work of Tao and colleagues that discovered a new pathway for triterpene biosynthesis in which bifunctional class I terpene synthases from fungi catalyze both the synthesis of HexPP and its cyclization via their prenyltransferase (PTd) and terpene cyclase (TCd) domains.

Courdavault V, Papon N. A new path for terpenoid biosynthesis. Trends Biochem Sci. 2022 Nov;47(11):906-908. doi: 10.1016/j.tibs.2022.07.004.
https://doi.org/10.1016/j.tibs.2022.07.004

Abstract

Triterpenes are C30 organic compounds abundantly found in all living organisms. Although previously believed to be exclusively produced from squalene or oxidosqualene, a recent report by Tao and colleagues describes a new triterpene biosynthetic route involving the cyclization of the precursor hexaprenyl diphosphate (HexPP) by unprecedented bifunctional terpene synthase (TS) enzymes.