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Gaining access to acetyl-CoA by peroxisomal surface display.

  • Pharmacie,
  • Santé-Sciences-Technologie,
Date(s)

du 26 mars 2023 au 26 août 2025

Lieu(x)

Site Grandmont

EA2106 BBV - Biomolécules et Biotechnologies végétales

A focus on Yocum and collaborator work who have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisomal membrane.

Perrot T, Besseau S, Papon N, Courdavault V. Gaining access to acetyl-CoA by peroxisomal surface display. Synth Syst Biotechnol. 2023 Mar 6;8(2):224-226. doi: 10.1016/j.synbio.2023.02.003. 

Abstract

Synthetic biology is constantly making progress for producing compounds on demand. Recently, Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisomal membrane. This allowed access to an untapped resource of acetyl-CoA and stimulated the synthesis of a valuable polyketide.

Keywords: 2-PS, 2-Pyrone synthase; Acc1, Acetyl-CoA carboxylase; Acetyl-CoA; Cat2, Carnitine acetyl-CoA transferase; CoA, Coenzyme A; Enzymes colocalization; Peroxisomal membrane; Polyketides; Synthetic biology; TAL, Triacetic acid lactone.